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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Heat-labile enterotoxin ： ウィキペディア英語版 Heat-labile enterotoxin Heat-labile enterotoxin is a type of labile toxin found in ''Escherichia coli'' and ''Bacillus cereus''. ==''Escherichia coli''== The heat labile enterotoxin is inactivated at high temperatures. It acts similarly to the cholera toxin by raising cAMP levels through ADP-ribosylation of the alpha-subunit of a Gs protein leading to the constitutive activation of adenylate cyclase. Elevated cAMP levels stimulate the activation of the CFTR channel thus stimulating secretion of Chloride ions and water from the enterocyte into the gut lumen. This ionic imbalance causes watery diarrhea. In addition to its effects on chloride secretion, which involve the same steps as the effects of cholera toxin, heat-labile enterotoxin binds additional substrates: lipopolysaccharide on the surface of ''E. coli'' cells and A-type blood antigens. The importance of these binding events is not yet known. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Heat-labile enterotoxin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.